Osteoarthritis just as severe as rheumatoid arthritis
European League Against Rheumatism, ttps://www.sciencedaily.com/releases/2016/06/160609115314.htm
June 9 2016, Rheumatologists more likely to underestimate clinical status of their OA patients than their RA patients.
Previous studies have shown that physicians and their patients with various rheumatic conditions, including RA, tend to rate the impact of the disease very differently. , Although recent evidence suggests similar disease burdens in both OA and RA, OA is still generally regarded as being less severe than RA.
In this new study, patient perception of disease severity was greater than physician assessment (by two Units or more) in one third of 243 OA patients and one fifth of 216 RA patients. The assessments of severity were equivalent in just over one half of OA and two thirds of RA patients. Physician evaluation of severity was greater than patient assessment (by two Units or more) in 10% of OA and 15% of RA patients. Physician and patient evaluation of disease severity are both based on a 0-10 visual analogue scale; patient assessment included completion of a multidimensional health assessment questionnaire, with scores for physical function, pain and fatigue, a symptom checklist, and a self-reported joint count.
Stem cell treatment for osteoarthritis of the knee may help rebuild lost cartilage
Published on March 23, 2015, News Medical
According to Director, Dr. Nathan Wei of the Arthritis Treatment Center, “Osteoarthritis options in the past have been limited to symptom relief. We are now entering an era where we have therapies that may also rebuild lost cartilage.”
Osteoarthritis (OA) is a disease due to loss of cartilage, the gristle that caps the ends of long bones and provides cushioning and shock absorption.
He goes on to say, “by administering adult stem cells, in a certain fashion, we may be able to restore lost cartilage. While this action has been demonstrated in multiple animal models, it has only been described in anecdotal reports in humans. Fortunately, we are now conducting clinical studies that are much better controlled and more scientifically valid.”
Dr. Wei adds, “The positive effect on arthritis is not only due to multiplication, division, and transformation of the stem cell into cartilage, but it is also due to the fact the stem cell releases proteins that attract other reparative cells to the area. This is called the ‘paracrine’ effect.”
“We are excited about the early results of our investigation and hope the results will continue to be positive. If so, I hope that knee replacement surgery might become a thing of the past,” he concludes.
Dr. Wei is a board-certified rheumatologist and regenerative medicine expert. He is director of the Arthritis Treatment Center located in Frederick, Maryland.
Stem Cell Mobilization Therapy may be Effective Against Osteoarthritis
Currently, Osteoarthritis (OA) treatment involves the use of anti-inflammatory drugs, analgesics, lubricating supplements, or surgery,” said study lead author Dr. Shih-Chieh Hung of the Department of Medical Research and Education at the Taipei Veterans general Hospital in Taiwan. “Recently, hematopoietic (blood) stem cells derived from bone marrow have emerged as a potential treatment for OA. We hypothesized that G-CSF-mobilized peripheral blood stem cells (gm-PBSCs) contain a population of primitive stem cells that have the capacity for mobility once released from stem cell niches.” “The researchers noted that the use of G-CSF administration in humans to treat other diseases and conditions has been found to be “safe and effective,” despite known side effects such as bone pain, headache, fatigue, and nausea which, they added, are generally “transient, self-limiting and without long-term consequences.””Although potential long-term adverse effects, such as malignancy after G-CSF administration have been reported, the frequency is low and the relationship between major adverse effects and G-CSF administration is not clear,” said Dr. Hung.
Walk 6,000 steps a day to keep osteoarthritis at bay
Daniel White, PT, ScD, from Sargent College at Boston University in Massachusetts said that the study examines if more walking equates with better functioning, and if so, how much daily walking is needed to minimize risk of developing problems with mobility in people with knee OA.The researchers measured daily steps taken by 1788 people with or at risk for knee OA, who were part of the Multicenter Osteoarthritis Study. Walking was measured with a monitor over seven days and functional limitation evaluated two years later, defined as a slow walking speed and a Western Ontario and McMaster Universities Arthritis Index (WOMAC) physical function score greater than 28 out of 68.Walking an additional 1,000 steps each was associated with between a 16 percent to 18 percent reduction in incident functional limitation two years later, while walking less than 6,000 steps daily was the best threshold for identifying those who developed functional limitation.